Nirmatrelvir and ritonavir are used in combination to treat adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) and have mild to moderate symptoms but are at risk of developing severe disease that could require hospitalization or result in death from viral disease 2019 (viral infection) brought on by the SARS-CoV-2 virus. The drug nirmatrelvir belongs to the antiviral drug class. It functions by preventing the virus’ internal propagation. Ritonavir belongs to the group of drugs known as pharmacokinetic boosters. It functions by making more nirmatrelvir accessible in the body, which increases the medication’s effectiveness.
How is this primovir to be taken?
Nirmatrelvir and ritonavir are combined in pills meant to be swallowed. Ritonavir and nirmatrelvir must be taken concurrently for the drug to be effective. It is often given twice a day for five days, with or without meals. Niramatrelvir and ritonavir should be taken at around the same times each day. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Primovir must be taken exactly as prescribed. Never take it in larger or smaller amounts or more frequently than directed by your doctor.
Do not chew, break, or crush the pills; instead, swallow them whole.
Take nirmatrelvir and ritonavir until you finish the prescription, even if you start to feel better. Do not stop taking nirmatrelvir and ritonavir without talking to your doctor. If you stop taking nirmatrelvir and ritonavir too soon or skip doses, your infection may not be completely treated.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
What special precautions should I follow?
Before taking nirmatrelvir and ritonavir,
- Tell your doctor and pharmacist if you are allergic to nirmatrelvir, ritonavir, any other medications, or any of the ingredients in nirmatrelvir or ritonavir tablets. Ask your pharmacist for a list of the ingredients.
- Inform your doctor if you are taking any of the following medications: alfuzosin (Uroxatral), amiodarone (Pacerone), apalutamide (Erleada), carbamazepine (Carbatrol, Epitol, Tegretol, Tegretol XR, among others), clozapine (Clozaril), colchicine, dihydroergotamine (DHEA), dronedarone (Multa (Halcion). If you are currently on one or more of these drugs, your doctor might advise against using nirmatrelvir with ritonavir.
- Inform your doctor and pharmacist about any other prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal items you are now taking or intend to use. Incorporate any of the following: Anticoagulants (also known as “blood thinners”) include warfarin (Coumadin), atorvastatin (Lipitor, in Caduet), bosentan (Tracleer), bupropion (Aplenzin, Forfivo, Wellbutrin, in Contrave), calcium channel blockers include amlodipine (Norvasc, in Caduet, in Tribenzor, among others), diltiazem (Cardizem, patches, hormonal vaginal rings, and othand pibrentasivir (Mavyret); ibrutinib (Imbruvica); ivosidenib (Tibsovo); mether ethinyl estradiol products; fentanyl (Actiq, Fentora, Lazanda, Subsys); glecaprevir adone (Methadose); neratinib (N (Medrol). mometasone (Asmanex, in Dulera) (Asmanex, in Dulera). prednisone, triamcinolone, trazodone, venetoclax (Venclexta), tacrolimus (Astagraf, Prograf), and voriconazole (Vfend). Your physician might need to adjust the dosage of your drugs or keep a close eye on you for adverse effects.
Inform your physician if you currently have HIV, renal illness, or liver disease.
Inform your doctor if you are expecting, want to get pregnant, or are nursing a baby. Call your doctor right away if you get pregnant while taking nirmatrel and ritonavir.
Nirmatrelvir and Ritonavir may lessen the efficacy of hormonal contraceptives; therefore, you should be aware of this (birth control pills, patches, rings, implants, injections, and intrauterine devices). While using ritonavir and nirmatrelvir, use another method of birth control or refrain from any sexual activity. As you undergo therapy with nirmatrelvir and ritonavir, discuss with your doctor the birth control methods that will be most effective for you.
What specific dietary recommendations should I abide by?
Keep eating normally unless your doctor instructs you differently.
How should I proceed if I forget to take a dose?
Take the missed Paxzen dosage as soon as you recall it if you forget to take it within eight hours of the scheduled time. In contrast, skip the missed dosage and go on with your usual dosing plan if you miss it by more than 8 hours. To make up for a missed dose, do not take a second one.
What negative effects may this medicine have?
Both ritonavir and nirmatrelvir might have negative consequences. If any of these symptoms are severe or do not go away, let your doctor know right away:
- changed tastes,
- constipation, and muscle pains
Some adverse effects can be quite harmful. Call your doctor right away and stop taking nirmatrelvir and ritonavir if you have any of these symptoms:
- reduced appetite
- your skin or the whites of your eyes becoming yellow.
- urine with a dark colour
- stools with a light colour
- rough skin
- abdominal pain